Figure 1.

Workflow for the investigation of lipids’ influence on the VBOF. The five lipids phosphatidylcholine (pchol), phosphatidylethanolamine (pe), phosphatidylinositol (pail), phosphatidylserine (ps), and cholesterol (chstol) were added together and individually to the VBOF. The stoichiometric coefficients were either an absolute value identical for all lipids, or the initial stoichiometric coefficient from the macrophage biomass function factorized with a multiplication-coefficient. For all scenarios, the influence of the different VBOFs on the objective value was analyzed. Additionally, potential antiviral targets were examined using reaction knock-outs.