| ACE-2 | angiotensin converting enzyme 2 |
| ADP | adenosine diphosphate |
| ADSL1 | adenylosuccinate lyase 1 |
| ADSL2 | adenylosuccinate lyase 2 |
| ADSS | adenylosuccinate synthase |
| AICART | phosphoribosylaminoimidazolecarboxamide formyltransferase |
| AIRCr | Phosphoribosylaminoimidazole carboxylase |
| AMP | adenosine monophospate |
| ASPCTr | aspartate carbamoyltransferase |
| ATP | adenosine triphosphate |
| CBPS | carbamoyl-phosphate synthase |
| COMBINE | Computational Modeling in Biology Network |
| COVID-19 | Coronavirus Disease 19 |
| Csp | Copy number of structural proteins |
| DHORD9 | dihydoorotic acid dehydrogenase |
| DHORTS | dihydroorotase |
| E | envelope |
| ERGIC | endoplasmic reticulum–Golgi intermediate compartment |
| FBA | flux balance analysis |
| fbc | flux balance constraints |
| FVA | flux variability analysis |
| GARFT | phosphoribosylglycinamide formyltransferase |
| GEM | genome-scale metabolic model |
| GISAID | Global Initiative on Sharing All Influenza Data |
| GK1 | guanylate kinase 1 |
| GLUPRT | glutamine phosphoribosyldiphosphate amidotransferase |
| hCOV | human coronavirus |
| hCoV-229E | human coronavirus 229E |
| ID | identifier |
| IMP | inosine monophosphate |
| IMPC | IMP cyclohydrolase |
| M | membrane |
| MERS | Middle East Respiratory Syndrome |
| Mv | viral molar mass |
| N | nucleocapsid |
| OMEX | Open Modeling EXchange format |
| OMPDC | orotidine-5’-phosphate decarboxylase |
| ORPT | orotate phosphoribosyltransferase |
| PPi | diphosphate |
| PRAGSr | phosphoribosylglycinamide synthase |
| PRAIS | phosphoribosylaminoimidazole synthase |
| PRASCS | phosphoribosylaminoimidazolesuccinocarboxamide synthase |
| PRFGS | phosphoribosylformylglycinamidine synthase |
| PRPPS | phosphoribosylpyrophosphate synthetase |
| RPI | ribose-5-phosphate isomerase |
| S | spike |
| SARS | Severe Acute Respiratory Syndrome |
| SARS-CoV-2 | Severe Acute Respiratory Syndrome coronavirus type 2 |
| SBML | Systems Biology Markup Language |
| TGEV | transmissible gastroenteritis virus |
| VBOF | viral biomass objective function |
| vRNP | viral ribonucleoprotein complexes |
| WT | wildtype |