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PG production. Membrane phospholipids are metabolized into AA by the PLA2, PLD, or PLC pathways. AA is then converted to PGs and IL by the COX and LOX pathways, respectively. The generated PGH2 is transformed to PGE2, PGD2, PGI2, PGF2α, and thromboxane A2 (TXA2) by individual enzymes, all of which function by binding to target receptors on their own cells or adjacent cells in an autocrine or paracrine manner.
