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. 2021 May 24;13(6):783. doi: 10.3390/pharmaceutics13060783

Table 3.

Output data analysis of the 4131 factorial design used for the formulation of RLX-EMLs.

Response p-Value R2 Adjusted R2 Predicted R2 Adequate Precision Significant Factors
Y1:VS (nm) <0.0001 0.9965 0.9937 0.9862 52.94 X1, X2
Y2:ZP (mV) 0.0031 0.9201 0.8534 0.7802 9.57 X1
Y3:EE (%) <0.0001 0.9859 0.9741 0.9434 26.42 X1, X2
Y4:RE (%) <0.0001 0.9917 0.9847 0.9667 34.92 X1, X2

RLX-EMLs, raloxifene hydrochloride emulsomes; PL:SL, lipoid: solid lipid weight ratio; SL type: solid lipid type; VS, vesicle size; ZP, zeta potential; EE, entrapment efficiency; RE, release efficiency after 6 h.