Figure 2.

Iso antagonizes the potentiation of I_GABA induced by Epi in Purkinje cells. (A) Representative traces of the current induced by 2 µM gamma-aminobutyric acid (GABA) in control and during co-application with different concentrations of Epi (left), 100 µM Iso (middle) and 50 µM Epi together with 100 µM Iso (right). (B) Concentration dependence of Epi and Iso effect on the normalized peak amplitude of I_GABA. (C) Mean ± standard error of the mean (SEM) of the normalized values of the peak amplitude of I_GABA in the presence of Epi (50 µM), Iso (100 µM), Epi + Iso, flumazenil (10 µM), Epi + flumazenil. The control value is indicated by a dashed line. Data points represent average from seven cells. *** Means p < 0.001, ns means not significant.