Table 2.
Results of human inflammation genes array after 2 weeks of fibroblast treatment with Onco-P20 (or not control cells). Results are the mean ± SD of seven different experiments performed with fibroblasts isolated from independent donors. * p < 0.05 and ** p < 0.001. Not detected.
| Target mRNA | Ctrl | Onco-P20 |
|---|---|---|
| A2M | 2.16 ± 4.53 | 12.6 ± 9.97 |
| ADRB1 | ND | ND |
| ADRB2 | 1.78 ± 3.07 | 3.87 ± 7.09 ** |
| ALOX12 | ND | ND |
| ALOX5 | ND | ND |
| ANXA1 | 1.70 ± 0.33 | 3.33 ± 1.06 ** |
| ANXA3 | 3.56 ± 2.07 | 3.40 ± 2.08 |
| ANXA5 | 1.56 ± 0.31 | 2.02 ± 0.54 |
| B2M | 0.43 ± 0.70 | 1.89 ± 1.21 ** |
| BDKRB1 | 0.23 ± 0.12 | 7.65±6.20 * |
| BDKRB2 | 0.33 ± 6.20 | 6.06 ± 5.31 * |
| CACN1C | 1.4 ± 0.69 | 1.7 ± 1.48 |
| CACN2D1 | ND | ND |
| CACNB2 | 1.07 ± 2.01 | 2.04 ± 1.63 |
| CACNB4 | 1.63 ± 2.95 | 4.07 ± 6.04 |
| CASP1 | 1.72 ± 0.65 | 4.84 ± 0.60 |
| CD40 | 2.57 ± 1.72 | 9.96 ± 4.45 ** |
| CD40LG | ND | ND |
| CES1 | 0.27 ± 0,19 | 0.89 ± 0.9 |
| CYSLTR1 | ND | 1.88 ± 2.01 |
| HPDG | ND | ND |
| HRH1 | 2.91 ± 0.99 | 2.33 ± 1.13 |
| HRH2 | ND | ND |
| HRH3 | ND | ND |
| HTR3A | ND | ND |
| HTR3B | ND | ND |
| ICAM1 | 0.42 ± 0.25 | 9.57 ± 6.17 ** |
| IL13 | ND | ND |
| IL1R1 | 0.98 ± 0.66 | 3.87 ± 2.12 * |
| IL1R2 | ND | ND |
| IL1RAPL2 | ND | ND |
| IL1RL1 | ND | ND |
| IL2RA | ND | ND |
| IL2RB | ND | ND |
| IL2RG | ND | ND |
| ITGAL | ND | ND |
| ITGAM | ND | ND |
| ITGB1 | 1.68 ± 0.29 | 2.96 ± 1.5 |
| ITGB2 | 0.51 ± 0.32 | 2.7 ± 1.74 * |
| KLK1 | ND | ND |
| KLK14 | 0.55 ± 0.93 | 6.08 ± 2.31 ** |
| KLK15 | ND | ND |
| KLK2 | ND | ND |
| KLK3 | ND | ND |
| KLKB1 | ND | ND |
| KNG1 | ND | ND |
| LTA4H | 1.21 ± 0.25 | 2.34 ± 0.78 * |
| LTB4R | 2.15 ± 0.87 | 2.82 ± 1.68 |
| LT4R2 | 0.81 ± 0.63 | 1.94 ± 1.55 |
| LTC4S | 0.53 ± 0.37 | 0.53 ± 0.28 |
| MAPK1 | 0.63 ± 0.48 | 0.62 ± 0.38 |
| MAPK14 | 1.11 ± 0.51 | 1.95 ± 1.01 |
| MAPK3 | 0.96 ± 0.27 | 1.40 ± 0.47 |
| MAPK8 | 1.33 ± 0.71 | 2.49 ± 0.99 |
| MC2R | ND | ND |
| NFKB1 | 0.28 ± 0.15 | 0.60 ± 0.38 |
| NOS2A | ND | ND |
| NR3C1 | 1.3 ± 0.33 | 1.9 ± 0.86 |
| PDE4A | 0.83 ± 0.24 | 1.03 ± 0.21 |
| PDE4B | 0.29 ± 0.13 | 2.59 ± 2.75 |
| PDE4C | ND | ND |
| PDE4D | 0.33 ± 0.42 | 4.50 ± 4.30 |
| PLA2G10 | ND | ND |
| PLA2G1B | ND | ND |
| PLA2G2A | ND | ND |
| PLA2G2B | ND | ND |
| PLA2G2D | ND | ND |
| PLA2G4C | 0.19 ± 0.15 | 2.63 ± 1.94 * |
| PLA2G5 | ND | ND |
| PLA2G7 | ND | ND |
| PDE4D | 0.33 ± 0.43 | 4.50 ± 4.3 |
| PLCB2 | ND | ND |
| PLCB3 | 0.77 ± 0.21 | 0.66 ± 0.15 |
| PLCB4 | 2.01 ± 1.77 | 1.23 ± 0.79 |
| PLCD1 | 1.19 ± 0.54 | 1.69 ± 0.47 |
| PLCE1 | 0.60 ± 0.63 | 0.36 ± 0.35 |
| PLCG1 | 7.26 ± 2.47 | 13.9 ± 1.18 |
| PLCG2 | 1.90 ± 1.28 | 2.99 ± 2.04 |
| PTAFR | 0.15 ± 0.34 | 1.08 ± 1.52 |
| PTGDR | 0.09 ± 0.2 | 8.30 ± 6.32 * |
| PTGER2 | 0.60 ± 0.41 | 4.06 ± 4.27 |
| PTGER3 | 2.5 ± 2.65 | 5.2 ± 2.97 |
| PTGFR | 1.0 ± 0.41 | 3.3 ± 2.43 |
| PTGIR | 0.80 ± 0.47 | 1.55 ± 0.54 * |
| PTGIS | 0.83 ± 0.84 | 2.57 ± 2.47 |
| PTGS1 | 0.65 ± 0.74 | 1.1 ± 0.50 |
| PTGS2 | 0.42 ± 0.49 | 6.42 ± 6.88 |
| TBXA2R | 0.8 ± 0.27 | 1.7 ± 0.78 * |
| TBXAS1 | ND | ND |
| TNF | ND | ND |
| TNFRSF1A | 1.4 ± 0.52 | 1.9 ± 0.93 |
| TNFRSF1B | 0.67 ± 0.54 | 2.48 ± 1.07 ** |
| TNFRSF13B | 1.2 ± 1.42 | 12.8 ± 9.62 * |
| VCAM1 | 0.3 ± 0.53 | 13.2 ± 21.6 |