Table 3.
Semi-quantitative analysis of multiple cytokines secreted by Onco-P20-treated fibroblasts after 2 weeks of continuous treatment. Data represent x-fold increase or decrease with respect to untreated cells. Results are the mean ± SD of four different experiments performed with fibroblasts isolated from independent donors. * p < 0.05 and ** p < 0.001.
| Target mRNA | Onco-P20 |
|---|---|
| (x-Fold Change) | |
| CCL11 | 2.65 ± 1.0 * |
| CCL24 | 1.16 ± 0.87 |
| GCSF | 0.57 ± 0.34 |
| GMCSF | 1.03 ± 0.44 |
| INGγ | 1.44 ± 0.61 |
| IL1α | 1.55 ± 1.09 |
| IL1β | 2.11 ± 1.58 |
| IL2 | 1.35 ± 0.60 |
| IL3 | 1.03 ± 0.59 |
| IL4 | 2.37 ± 2.12 |
| IL6 | 8.65 ± 4.84 * |
| IL7 | 0.85 ± 0.61 |
| IL8 | 4.40 ± 1.64 ** |
| IL10 | 1.22 ± 0.61 |
| IL11 | 0.90 ± 0.43 |
| IL12p40 | 0.96 ± 0.71 |
| IL12p70 | 2.19 ± 2.20 |
| IL13 | 0.73 ± 0.57 |
| CCL1 | 0.26 ± 0.31 * |
| TIMP-2 | 0.81 ± 0.2 |