Figure 5.
The mitochondrial antioxidant MitoTEMPO (MitoT) decreases but does not abolish carotid body (CB) chemoafferent responses to hypoxia. (a) Raw CB chemoafferent recording of the response to hypoxia ± 20 μM MitoT. Raw voltage is shown (upper) along with frequency histograms (lower). Inset: overdrawn action potentials from a single fibre. (b) PO2-chemoafferent frequency response curves from a single experiment corresponding to the example shown in (a). (c) Mean chemoafferent hypoxic response curves for paired control and 20 μM MitoT (n = 9 fibres, N = 6 animals). Data are presented as mean ± SEM. ** denotes p < 0.01 MitoT vs. control, two-way repeated measures ANOVA.