Skip to main content
. 2021 May 25;10(6):840. doi: 10.3390/antiox10060840

Figure 8.

Figure 8

The mitochondrial antioxidant SKQ1 decreases the hypoxic ventilatory response (HVR). (a) Representative respiratory traces (tidal volume (VT) vs. time, 5 s) illustrating breathing pattern before (left) and after (right) SKQ1 administration (500 nM kg−1, I.P.), in normoxia (21% O2) and during hypoxia (10% O2). (b–d) Mean Rf in normoxia, hypoxia, and the relative change, respectively, before and after SKQ1 (N = 6 animals). (e–g) Mean minute ventilation (VE) in normoxia, hypoxia, and the relative change (HVR), before and after SKQ1. Data presented in box and whisker plots show mean (+), median line with a box range of 25th and 75th percentiles and outlier whiskers at minimum and maximum. Single points represent individual animals. * and **** denote p < 0.05 and p < 0.001 control vs. SKQ1 respectively, paired t-test.