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. 2021 May 24;44(6):214–223. doi: 10.1097/CJI.0000000000000374

FIGURE 3.

FIGURE 3

The correlation between PMEL over-expression gene and OS of SKCM in GEPIA and TIMER database (A−D). A, High PMEL expression level corresponded with poor OS prognosis of SKCM in GEPIA database (HR=1.5, log-rank P=0.0058, cutoff value, 50%). B−D, High PMEL expression level correlated with poor OS prognosis of SKCM, SKCM-metastasis and SKCM-primary in TIMER (cutoff value, 50%). The Kaplan-Meier overall survival curves comparing the high and low-expression levels of PMEL in various types of cancer in PrognoScan (E, F). E and F, High PMEL expression level corresponded with poor OS prognosis in melanoma and lung cancer, respectively (P<0.05; cutoff value, 75% and 50%, respectively). GEPIA indicates Gene Expression Profiling Interactive Analysis; HR, hazard ratio; OS, overall survival; PMEL, premelanosome protein; SKCM, skin cutaneous melanoma; TCGA, The Cancer Genome Atlas; TIMER, Tumor Immune Estimation Resource.