TABLE 1.
The Analysis of Correlation Between the Expression of PMEL and Clinicopathologic Characteristics of SKCM Based on TMA
| PMEL Expression [n (%)] | ||||
|---|---|---|---|---|
| Clinicopathologic Characteristics | Numbers | Low | High | P |
| Sex | ||||
| Male | 31 | 23 (46.0) | 8 (16.0) | 0.230* |
| Female | 19 | 11 (22.0) | 8 (16.0) | |
| Age (y) | ||||
| ≤60 | 30 | 21 (42.0) | 9 (18.0) | 0.710* |
| >60 | 20 | 13 (26.0) | 7 (14.0) | |
| Tumor location | ||||
| Limbs | 27 | 19 (38.0) | 8 (16.0) | 0.364* |
| Trunk | 5 | 2 (4.0) | 3 (6.0) | |
| Head and neck | 18 | 13 (26.0) | 5 (10.0) | |
| Clark grade | ||||
| I−II | 18 | 16 (32.0) | 2 (4.0) | 0.026 † |
| III−V | 32 | 18 (36.0) | 14 (28.0) | |
| Breslow (mm) | ||||
| ≤11 | 24 | 17 (34.0) | 7 (14.0) | 0.680* |
| >11 | 26 | 17 (34.0) | 9 (18.0) | |
| Tumor diameter (cm) | ||||
| ≤2 | 28 | 19 (38.0) | 9 (18.0) | 0.981* |
| >2 | 22 | 15 (30.0) | 7 (14.0) | |
| Ulcer | ||||
| Yes | 20 | 10 (20.0) | 10 (20.0) | 0.026 * |
| No | 30 | 24 (48.0) | 6 (12.0) | |
| Nerve invasion | ||||
| Yes | 20 | 14 (28.0) | 6 (12.0) | 0.804* |
| No | 30 | 20 (40.0) | 10 (20.0) | |
| Vascular tumor thrombus | ||||
| Yes | 26 | 17 (34.0) | 9 (18.0) | 0.680* |
| No | 24 | 17 (34.0) | 7 (14.0) | |
| AJCC stage (TNM) | ||||
| I−II | 29 | 23 (46.0) | 6 (12.0) | 0.044 * |
| III−IV | 21 | 11 (22.0) | 10 (20.0) | |
Bold values indicate statistical significance (P<0.05).
*
Pearson χ2 test.
†
Fisher exact test.
AJCC indicates American Joint Committee on Cancer; PMEL, premelanosome protein; SKCM, skin cutaneous melanoma; TMA, tissue microarray.