TABLE 2.
Correlation Analysis Between PMEL/SILV and Relate Gene Markers of Immune Cells in TIMER Database
| SKCM | SKCM-metastasis | ||||
|---|---|---|---|---|---|
| Description | Gene Markers | Correlation | P | Correlation | P |
| CD8+ T cell | CD8A | −0.139 | ** | −0.106 | 0.0412 |
| CD8B | −0.116 | 0.012 | −0.078 | 0.134 | |
| Monocyte | CD86 | −0.283 | *** | −0.249 | *** |
| CD115 (CSF1R) | −0.335 | *** | −0.307 | *** | |
| CD14 | −0.302 | *** | −0.272 | *** | |
| TAM | CCL2 | −0.305 | *** | −0.287 | *** |
| CD68 | 0.085 | 0.072 | 0.088 | 0.093 | |
| IL10 | −0.238 | *** | −0.205 | *** | |
| M1 macrophage | NOS2 | 0.045 | 0.328 | 0.075 | 0.154 |
| IRF5 | −0.076 | 0.102 | −0.033 | 0.526 | |
| PTGS2 | −0.281 | *** | −0.308 | *** | |
| M2 macrophage | CD163 | −0.297 | *** | −0.269 | *** |
| VSIG4 | −0.277 | *** | −0.246 | *** | |
| MS4A4A | −0.297 | *** | −0.267 | *** | |
| Neutrophils | CEACAM8 | −0.075 | 0.105 | −0.09 | 0.084 |
| CD11b (ITGAM) | −0.244 | *** | −0.208 | *** | |
| CCR7 | −0.035 | 0.443 | −0.033 | 0.534 | |
| Dendritic cell | HLA-DPB1 | −0.172 | ** | −0.139 | * |
| HLA-DQB1 | −0.126 | * | −0.092 | 0.078 | |
| HLA-DRA | −0.21 | *** | −0.177 | ** | |
| HLA-DPA1 | −0.143 | * | −0.099 | 0.057 | |
| BDCA-1 (CD1C) | −0.219 | *** | −0.205 | *** | |
| BDCA-4 (NRP-1) | −0.522 | *** | −0.539 | *** | |
| CD11C (ITGAX) | −0.075 | 0.104 | −0.024 | 0.639 | |
| Th1 | T-bet (TBX21) | −0.144 | * | −0.117 | 0.025 |
| STAT4 | −0.34 | *** | −0.298 | *** | |
| STAT1 | −0.105 | 0.023 | −0.065 | 0.215 | |
| IFN-γ (IFNG) | −0.135 | * | −0.11 | 0.035 | |
| TNF-α (TNF) | −0.107 | 0.020 | −0.115 | 0.027 | |
| Th2 | GATA3 | −0.194 | *** | −0.212 | *** |
| STAT6 | 0.192 | *** | 0.237 | *** | |
| STAT5A | 0.243 | *** | 0.305 | *** | |
| IL13 | −0.174 | ** | −0.184 | ** | |
| Tfh | BCL6 | −0.39 | *** | −0.365 | *** |
| IL21 | −0.133 | * | −0.1 | 0.055 | |
| Th17 | STAT3 | −0.16 | ** | −0.146 | * |
| IL17A | 0.078 | 0.091 | 0.036 | 0.497 | |
| Treg | FOXP3 | −0.101 | 0.028 | −0.088 | 0.094 |
| CCR8 | −0.219 | *** | −0.186 | ** | |
| STAT5B | −0.091 | 0.048 | −0.053 | 0.311 | |
| TGFβ (TGFB1) | −0.303 | *** | −0.31 | *** | |
| T cell exhaustion | PD-1 (SNCA) | 0.539 | *** | 0.582 | *** |
| CTLA4 | −0.061 | 0.184 | −0.079 | 0.128 | |
| LAG3 | −0.13 | * | 0.098 | 0.060 | |
| TIM-3 (HAVCR2) | −0.226 | *** | −0.191 | ** | |
| GZMB | −0.118 | 0.010 | −0.111 | 0.038 | |
None indicates without adjustment; Purity, adjusted by tumor purity; PMEL, premelanosome protein; SILV, silver homologue; SKCM, skin cutaneous melanoma; SKCM-metastasis, the metastasis of skin cutaneous melanoma; TAMs, tumor-associated macrophages; Tfh, follicular helper T cell; Th1, T helper cell 1; Th2, T helper cell 2; Treg, regulatory T cell; TIMER, Tumor Immune Estimation Resource.
*
P<0.01.
**
P<0.001.
***
P<0.0001.