a, Absolute weight of WT and Fgr KO mice in NNT WT or KO background fed in high fat diet (HFD) for 8 weeks (in NNTWT background, n = 11; in NNTKO background n = 26). b, Insulin (upper panel) and c-peptide (bottom panel) levels after glucose injection (insulin release assay) in WT (solid circles) and FgrKO (open triangles) mice in NNTWT or NNTKO background fed high fat diet. (In b for insulin levels: in NNT WT background, n = 7; in NNTKO background n≥18: for c-peptide levels, n = 7). c-d, Water (c) and food (d) intake by mice assessed in metabolic cages for 48 hours. e, O2 consumption (VO2), (f) CO2 production (VCO2), and (g) energy expenditure (EE) measured in mice in metabolic cages for 48 hours (n = 6). Each point represents a biological replicate. Data are the mean ± SEM.