Fig. 1.

SARS-CoV-2 infection is link to circadian rhythm. (A) Circadian rhythm of BMAL1 and CLOCK genes in monocytes using Cosinor model from 4 different donors. (B) Virus load (n = 4) and titers (n = 3) at CT6 and CT17 time from experiments that were repeated 3 times using at least 3 different donors. (C) Representative pictures and phagocytosis activity of monocytes (F-actin in green and nucleus in blue) infected by SARS-CoV-2 virus (red). Results are expressed as the mean ± SEM of 4 donors with 3 independent experiments. (D) Level of IL-6, IL-1β and IL-10 of unstimulated (red) and infected cells at CT6 and CT17. Results are expressed as the mean of 4 donors from 3 independent experiments. . (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)