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Pharmacokinetic profiling and dosage optimization of LEAF-4L6715 in 18 COVID-19 patients. (A) PK profile of total TC from LEAF-4L6715 over a 3-day period with a daily injection of 2.5 mg/kg in cohort 1 (n = 6) and an initial loading dose of 5 mg/kg followed by a daily injection of 2.5 mg/kg LEAF-4L6715 in cohort 2 (n = 6). (B) PK profile of free TC over a 24 h period for 2.5 mg/kg and 5 mg/kg injections of LEAF-4L6715.
