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. 2021 Jun 24;336:252–261. doi: 10.1016/j.jconrel.2021.06.033

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© 2021 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 6 — LEAF-4L6715 efficiently improved the oxygenation of COVID-19 patients in cohort 1 and 2 (n = 6/group). (A) Validation of the major endpoint criteria of the study, including PaO₂/FiO₂ ratio, PEP, PaCO₂, noradrenaline status, and position of the patients 3 days before and 3 days after the first injection of LEAF-4L6715. (B) Mean adjusted SOFA score along with cardiovascular and respiratory SOFA subscores. All data are presented as the mean ± standard error of the mean. The adjusted SOFA score excludes the liver biology to avoid the interference with the AE related to the LEAF-4L6715 exposure. Wilcoxon tests were performed to compare the different increase of PaO₂/FiO₂ within the same group and the SOFA scores evolutions. **p-value<0.01.