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Pharmacokinetic properties of LEAF-4L6715 in 12 patients with COVID-19. (Top) Total drug concentration in the blood, (bottom) released trans-crocetin (free drug) in the blood.
| Cohort | N | Kel24h | R24h | T1/2 (h) | Ctrough (μg/mL) | Cmax (μg/mL) | AUC0-t (h*μg/mL) | Vz (L) | Cl (L/h) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Total drug | 1 | 6 | 0.08 | 0.92 | 9.44 | 4.70 | 36.13 | 263.78 | 7.78 | 0.08 |
| 2 | 6 | 0.07 | 0.88 | 10.35 | 12.51 | 75.37 | 635.46 | 7.50 | 0.62 | |
| Free drug | 1 | 6 | 0.11 | 0.62 | 7.53 | 2.38 | 18.68 | 132.20 | 15.66 | 1.93 |
| 2 | 6 | 0.09 | 0.83 | 8.43 | 4.88 | 47.42 | 311.59 | 13.52 | 1.51 |
