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ROC and PR analysis of the ProPred score’s utility to design variants with favorable NetMHCII scores. A NetMHCII score that is (A) 33% and (B) 50% of the wild-type score were considered to be “favorable” scores in this analysis. Designs with no PSSM restrictions and base 2 log odds constraints of 1, 2, and 3 were considered separately. See also Figure S14–Figure S17.
