Table 2.
Accumulated data obtained from the ultrastructural analysis of the neuropil from Layers II and III of the EC
| EC layer |
Group | No. AS |
No. SS |
No. all synapses |
% AS (mean ± SD) |
% SS (mean ± SD) |
CF volume (μm3) |
No. AS/μm3 (mean ± SD) |
No. SS/μm3 (mean ± SD) |
No. all synapses/μm3 (mean ± SD) |
Distance to nearest neighbor (nm; mean ± SD) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| II | Control | 1553 | 137 | 1690 | 91.90 ± 2.62 | 8.10 ± 2.62 | 4221 (5445) | 0.37 ± 0.05 (0.38 ± 0.06) | 0.03 ± 0.01 (0.03 ± 0.01) | 0.40 ± 0.03 (0.41 ± 0.06) | 840 ± 35 (811 ± 33) |
| Alzheimer | 954 | 90 | 1044 | 90.53 ± 4.27 | 9.47 ± 4.27 | 4409 (5742) | 0.21 ± 0.09 (0.23 ± 0.09) | 0.02 ± 0.01 (0.02 ± 0.01) | 0.24 ± 0.09 (0.25 ± 0.09) | 938 ± 113 (906 ± 109) | |
| III | Control | 1747 | 130 | 1877 | 92.84 ± 1.97 | 7.16 ± 1.978 | 4371 (5466) | 0.40 ± 0.09 (0.42 ± 0.09) | 0.03 ± 0.01 (0.03 ± 0.01) | 0.43 ± 0.01 (0.45 ± 0.09) | 852 ± 42 (823 ± 41) |
| Alzheimer | 973 | 92 | 1065 | 92.12 ± 5.70 | 7.88 ± 5.70 | 4597 (5653) | 0.22 ± 0.06 (0.23 ± 0.08) | 0.02 ± 0.02 (0.02 ± 0.02) | 0.24 ± 0.08 (0.25 ± 0.09) | 1004 ± 214 (970 ± 206) |
All volume data are corrected for shrinkage factor. Data in parentheses are not corrected with the shrinkage and the fixation artifact factors. The data for individual cases are shown in Extended Data Table 2-1.