Table 3.
Area (mean ± SEM, in nm2) and perimeter (mean ± SEM, in nm) of the SAS in Layers II and III of the EC
| EC layer | Group | Type of synapse (no. of synapses) | Area of SAS | Perimeter of SAS |
|---|---|---|---|---|
| II | Control | AS (1552) | 110,311 ± 3229 (102,865) | 1631 ± 47 (1575) |
| SS (139) | 65,997 ± 6041 (61,543) | 1404 ± 73 (1356) | ||
| Alzheimer | AS (952) | 136,166 ± 10,773 (126,976) | 1819 ± 52 (1757) | |
| SS (90) | 59,232 ± 6589 (55,234) | 1239 ± 72 (1196) | ||
| III | Control | AS (1746) | 124,183 ± 3265 (115,801) | 1826 ± 67 (1763) |
| SS (129) | 67,445 ± 3243 (62,893) | 1399 ± 75 (1351) | ||
| Alzheimer | AS (973) | 122,727 ± 10,453 (114,444) | 1720 ± 116 (1661) | |
| SS (94) | 57,271 ± 14,132 (56,082) | 1343 ± 272 (1348) |
Data on area and perimeter are corrected for shrinkage factor (data in parentheses are not corrected with the shrinkage and the fixation artifact factors). The data for individual cases are shown in Extended Data Table 3-1.