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. 2021 Mar 17;48(4):525–541. doi: 10.1007/s10928-021-09747-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Time profiles of model-predicted verinurad (ER8 formulation) and febuxostat concentration, FEUA, sUA reduction and uric acid renal excretion rate. Simulation with variability (see “Methods” section for details). Simulations were performed assuming following baseline characteristics: eGFR = 60 mL/min/1.73 m²; baseline sUA = 8.5 mg/dL; baseline FEUA = 7.7%; non-Asian; verinurad ER8 formulation given in fed state. FEUA fractional excretion of uric acid, sUA serum uric acid