Table 3.

Mean peak effects during controlled cannabis administration (2 days of 7.0% THC 6x/day) and during cannabis abstinence (3 days) as a function of lorcaserin dose (0, 10 mg BID).

Measure	Lorcaserin Dose	Cannabis Administration	Abstinence
Ratings of “Sociable”	0 mg	53.6 (2.7)	47.8 (2.3)
	10 mg	⬆ 57.9 (2.9)*	46.3 (2.3)
Cannabis Craving	0 mg	68.2 (5.6)	66.2 (5.4)
	10 mg	64.7 (6.3)	⬇ 57.4 (6.1)
Digit-Recall (#)	0 mg	6.9 (0.2)	7.2 (0.2)
	10 mg	⬇ 6.2 (0.4)*	⬇ 6.7 (0.2)**
Rapid Information	0 mg	81.3 (6.8)	74.2 (5.0)
Task (# misses)	10 mg	⬆ 98.8 (8.3)**	⬆ 86.3 (7.0)*
Food intake (kcal)	0 mg	4515.4 (446.5)	2426.0 (255.4)
	10 mg	4237.0 (566.5)	2331.7 (340.0)
Body weight (kg)	0 mg	82.7 (3.5)	81.7 (2.7)
	10 mg	⬆ 83.2 (3.4)*	⬆ 82.3 (2.6)*
Fell Asleep Easily	0 mg	69.2 (4.9)	58.6 (5.6)
	10 mg	58.6 (5.6)	⬇ 35.1 (4.1)**
Slept Well	0 mg	63.0 (4.7)	55.8 (5.3)
	10 mg	59.1 (3.9)	⬇ 46.2 (3.8)**
“Drug Liking”	0 mg	0.37 (0.15)	0.29 (0.13)
	10 mg	⬆ 0.87 (0.24)*	0.00 (0.00)
“Strong Drug Effect”	0 mg	0.87 (0.22)	0.58 (0.19)
	10 mg	⬆ 1.3 (2.2)*	0.44 (016)
“Good Drug Effect”	0 mg	0.8 (0.21)	0.38 (0.19)
	10 mg	⬆ 1.3 (0.27)*	0.27 (0.16)
Tobacco Cigarettes (# ad lib)	0 mg	7.9 (3.7)	7.8 (1.5)
	10 mg	⬇ 5.9 (2.5)*	7.0 (1.3)

Note: Data in parentheses represent standard error of the mean. Mood/sleep rating range = 0 to100 mm; “Drug Liking” = −4 (dislike very much) to 4 (like very much); “Strong Drug Effect” and “Good Drug Effect” = 0 (none) to 4 (very); subjective drug effects are reflective of capsule effects.

Asterisks represent significant differences between lorcaserin and placebo * p < 0.02, ** p < 0.004, and the arrow signs indicate the direction of the effect.