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Mutation of Aromatic Cage Residues to Assess the Key Molecular Interactions between UNC6641 and the PHF1 Tudor Domain
| UNC7643 | ||
|---|---|---|
 |
Mutation | ITC Kd(μM) |
| WT | 10.1 ± 1.7 | |
| W41A | >100 | |
| Y47A | >100 | |
| F65A | >100 | |
| UNC6641 | ||
 |
Mutation | ITC Kd (μM) |
| WT | 0.96 ± 0.03 | |
| W41A | 4.9 ± 0.6 | |
| Y47A | >100 | |
| F65A | 13.7 ± 1.3 | |
Kd values were determined by two independent ITC experiments (mean ± SD).
