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. Author manuscript; available in PMC: 2021 Jun 25.
Published in final edited form as: J Am Chem Soc. 2021 Jun 8;143(23):8902–8910. doi: 10.1021/jacs.1c03852

Figure 1.

Figure 1.

A schematic diagram of the TF-PROTAC strategy. A BCN-modified VHL ligand (VHLL-X-BCN) is incorporated onto an azide-modified DNA oligomer (N3-ODN) via a copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) reaction, forming a TF-PROTAC to recruit the VHL E3 ubiquitin ligase to ubiquitinate the transcription factor (TF) of interest, which is subsequently degradated by the 26S proteasome.