Table 2.
Summary of consensus immunogenetic findings from two study cohorts.
| Locus | Variant (allele or aa residue) | Setting | Association | Reference(s) |
|---|---|---|---|---|
| IL19 | rs12407485-Aa | HESNs | Resistance to HIV-1 acquisition | [43] |
| HLA-A | A*68:02b | HESNs | Susceptibility to HIV-1 acquisition | [19] |
| HLA-B | B*57b | SPs | HIV-1 transmission | [17, 78] |
| HLA-B | Alleles carrying P2-Metc | HESNs | Susceptibility to HIV-1 acquisition | [6] |
a
Within a predicted enhancer region. According to a recent (March 2021) search in PhenoScanner (version 2), rs12407485 is a well-recognized eQTL, being associated with the expression of four genes (CD55, IL10, IL19 and IL24).
b
Confirmative results from the Rwandan cohort have not been published.
c
Mostly B*57:03 and often reflected by its persistent impact on viral load
d
Methionine at position 2 of a leader peptide that binds to HLA-E; also supported by in vitro assays [6].