Table 3.
Locus | Variant (allele or aa residue) | Setting | Association | Reference(s) |
---|---|---|---|---|
HLA-A | A*36:01a | Zambian SPs | Promoting HIV-1 transmission | Ref. [17] |
HLA-B | Alleles sharingb | Both partners | Promoting HIV-1 transmission | Ref. [2] |
KIR2DS4 | Full-length allele *001c | Zambian SPs | Promoting HIV-1 transmission | Ref. [18] |
Observation was confirmed multiple times in expanded cohorts (e.g., Figure 2), with clear impact on viral load in the SP partners.
Supported by experimental evidence [8].
The only allele encoding a functional, full-length receptor, with implications for inflammation mediated through natural killer cells [7].