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. Author manuscript; available in PMC: 2022 Jun 25.
Published in final edited form as: Circ Res. 2021 Apr 23;129(1):50–62. doi: 10.1161/CIRCRESAHA.120.317532

Figure 7.

Figure 7.

A-E: Vascular reactivity in mesenteric arteries by wire myography in control and mutant sPRR mice at basal conditions (n=5 mice/group); Comparison between control and mutant sPRR mice using two-way ANOVA with Bonferroni correction; F: Vascular reactivity to Ang-II at 10−7 M in mesenteric arteries in control and mutant sPRR mice (n=3 mice/group). Mesenteric arteries were pre-treated with NG- Methyl-L-Arginine acetate (L-NMMA, NOS inhibitor), indomethacin (COX inhibitor), apamin + charybdotoxin (EDHF blocker) or tempol (SOD mimetic). Results displayed are average of two mesenteric artery segments obtained from each mouse. Comparison between control and mutant sPRR mice was performed using Mann-Whitney non-parametric test.