Table 2.
Prevalence of AR-FL and AR-V7 in large RNA-Seq data sets from patients with primary or metastatic prostate cancer.
| 505 primary prostate cancer samples (TCGA) | |
|---|---|
| AR-FL positive | 98% (496 in 505) samples |
| AR-V7 positive | 29% (147 in 505) samples |
| AR-FL reads range | 0–364 (mean: 55.9) |
| AR-V7 reads range | 0–72 (mean: 3.4) |
| 98 mCRPC samples (SU2C) | |
|---|---|
| AR-FL positive | 97% (95 in 98) samples |
| AR-V7 positive | 79% (77 in 98) samples |
| AR-FL reads range | 0–23321 (mean: 3771.5) |
| AR-V7 reads range | 0–852 (mean: 82.3) |
Expression of AR-FL and AR-V7 was determined in primary prostate cancer samples (TCGA, n = 505) and mCRPC samples (SU2C, n = 98) by RNA-Seq data analysis using specific exon mapping reads as described in “Methods”. Transcript prevalence was calculated in both datasets and is displayed along with transcript expression range and mean.