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. 2021 Jun 24;11:13251. doi: 10.1038/s41598-021-92784-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ex vivo phagocytic capacity is variable between MNP subsets in different kidney injury models. CD11b + CD11c + -sorted cells from kidneys from naïve C57BL6/J (n = 11), 24 h after IRI (n = 7) and 3 days after UUO (n = 3) were fed PE + latex-beads for 2 h and phagocytic cells were identified as PE + events. Phagocytic cells were further dissected with our gating strategy for MNP subsets and CD206 + and CD86 + MHCII + CD206- cells. The data of each replicate were plotted either as (A) relative change compared to CD86 + MHCII + CD206- cells [%phagocytic cells/%phagocytic cells in CD86 + MHCII + CD206-] or (B) as relative change compared to MNP subset 1 [%phagocytic cells/%phagocytic cells in MNP1]. Data from two to three independent experiments are shown. Kruskal–Wallis test followed by Dunn’s multiple comparisons tests against M1 (A) or Friedman with post-hoc Dunn’s multiple comparisons (B) *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.