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. 2021 Jun 23;218(8):e20210279. doi: 10.1084/jem.20210279

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© 2021 Ma et al.

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Figure 5. — NK cell effector functions require YTHDF2.(A) Representative histograms showing expression of the indicated molecules in splenic NK cells from Ythdf2^WT and Ythdf2^ΔNK mice. (B and C) Representative plots (B) and quantification (C) of IFN-γ expression by splenic NK cells from Ythdf2^WT and Ythdf2^ΔNK mice when stimulated with or without IL-12 plus IL-18 or YAC-1 mouse lymphoma cells (n = 6 per group; at least three independent experiments). (D) Mice were treated with an injection of poly(I:C) (200 µg i.p.) for 18 h. Poly(I:C)-activated NK cells were isolated from the spleen and cocultured with MHC class I–deficient RMA-S cells at a ratio of 5:1, 2.5:1, and 1.25:1. Cytotoxicity of NK cells was evaluated by standard ⁵¹Cr release assays (n = 3 per group; at least two independent experiments). Data are shown as mean ± SD and were analyzed by two-way ANOVA with Šídák post-test. **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. E:T, effector:target.