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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Curr Opin Biotechnol. 2020 Dec 25;69:43–51. doi: 10.1016/j.copbio.2020.12.005

Figure 3.

Figure 3

Hemoprotein-catalyzed nitrene transfer reactions. (a) Selected nitrene donors and acceptors in enzymatic nitrene transfer reactions. Azide-based nitrene precursors are widely used in abiological nitrene transformations. Nitrene sources that contain N–O bonds are also suitable reagents for enzymes [46●,47●]. The corresponding nitrene species can react with unsaturated π-systems, thioether-based nucleophiles, and C–H coupling partners [11,43–45●]. (b) Recent advances include development of novel synthetic methods [46●,47●] and applications in cell imaging [50●].