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. 2021 Jun 24;11:13260. doi: 10.1038/s41598-021-92751-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IL-6 treatment alters kidney growth in vivo and in vitro. (A) Representative images newborns and (B) newborn kidneys from control dams and those treated with IL-6 (10 pg/g BWT, ip) every other day (E12.5–E20). Maternal IL-6 treatment resulted in smaller body size and kidneys in the newborn compared to pups born to control dams. Box plots show the distribution of (C) body weights and (D) kidneys by sex. Body and kidney weights in both sexes were significantly different between control (n = 53) and IL-6 groups (n = 48) (see text for details). (E) Mouse fetal metanephroi isolated at E13.5 were grown in vitro with 10 pg/mL (IL-6) or without (Control) for 0, 24, 48 and 72 h. IL-6 caused decrease in the growth of metanephric kidneys determined by reduction in surface area.