. 2021 Jun 24;11:13243. doi: 10.1038/s41598-021-92618-w

Table 3.

Analysis of MDT participant status and other factors affecting survival of esophageal patients.

Variables	Total		Survival		Death		P value^a	Adjusted			P value^b
Variables	N	%	n₁	%	n₂	%	P value^a	HR	95% CI		P value^b
Total	5906	100.00	1522	25.77	4384	74.23
MDT participant status							< 0.001
No	2953	50.00	698	23.64	2255	76.36
Yes	2953	50.00	824	27.90	2129	72.10		0.73	0.67	0.79	< 0.001
Gender							< 0.001
Female	373	6.32	145	38.87	228	61.13		–	–	–	–
Male	5533	93.68	1377	24.89	4156	75.11		1.45	1.01	2.09	0.043
Age at diagnosed (year)							0.001
< 45	486	8.23	108	22.22	378	77.78		–	–	–	–
45–54	1966	33.29	464	23.60	1502	76.40		1.29	0.88	1.89	0.189
55–64	2046	34.64	584	28.54	1462	71.46		1.19	0.84	1.68	0.333
65–74	865	14.65	233	26.94	632	73.06		1.30	0.90	1.87	0.163
≧ 75	543	9.19	133	24.49	410	75.51		1.33	0.83	2.15	0.239
Monthly salary (NTD)							< 0.001
≦ 17,280	1606	27.19	316	19.68	1290	80.32		–	–	–	–
17,281–22,800	2421	40.99	625	25.82	1796	74.18		0.74	0.55	1.01	0.047
22,801–28,800	472	7.99	147	31.14	325	68.86		0.76	0.49	1.18	0.214
28,801–36,300	510	8.64	140	27.45	370	72.55		0.65	0.45	0.94	0.023
36,301–45,800	598	10.13	196	32.78	402	67.22		0.60	0.29	1.22	0.159
≧ 45,801	299	5.06	98	32.78	201	67.22		0.42	0.23	0.75	0.003
Urbanization level							0.310
Level 1	1460	24.72	404	27.67	1056	72.33		–	–	–	–
Level 2	1715	29.04	437	25.48	1278	74.52		0.93	0.62	1.41	0.737
Level 3	1020	17.27	283	27.75	737	72.25		1.02	0.56	1.84	0.958
Level 4	872	14.76	195	22.36	677	77.64		0.98	0.51	1.90	0.954
Level 5	204	3.45	47	23.04	157	76.96		0.51	0.29	0.91	0.022
Level 6	342	5.79	81	23.68	261	76.32		0.68	0.40	1.16	0.159
Level 7	293	4.96	75	25.60	218	74.40		1.19	0.64	2.19	0.584
Other catastrophic illness							0.591
No	5673	96.05	1457	25.68	4216	74.32		–	–	–	–
Yes	233	4.96	65	27.90	168	72.10		1.78	1.16	2.74	0.009
Charlson Comorbidity index							0.280
0	3610	61.12	917	25.40	2693	74.60		–	–	–	–
1	1368	23.16	363	26.54	1005	73.46		1.02	0.78	1.33	0.891
2	525	8.89	134	25.52	391	74.48		0.98	0.67	1.43	0.912
≧ 3	403	6.82	108	26.80	295	73.20		0.99	0.58	1.69	0.963
Cancer stage							< 0.001
I	236	4.00	144	61.02	92	38.98		–	–	–	–
II	1154	19.54	445	38.56	709	61.44		1.18	0.70	2.01	0.533
III	3215	54.44	824	25.63	2391	74.37		2.75	1.78	4.26	< 0.001
IV	1301	22.03	109	8.38	1192	91.62		6.49	3.88	10.85	< 0.001
Treatment							< 0.001
Surgery	476	8.06	218	45.80	258	54.20		–	–	–	–
Radiotherapy	303	5.13	33	10.89	270	89.11		2.41	1.66	3.49	< 0.001
Chemotherapy	247	4.18	44	17.81	203	82.19		2.62	1.76	3.89	< 0.001
Surgery + radiotherapy	287	4.86	59	20.56	228	79.44		1.09	0.76	1.56	0.647
Surgery + chemotherapy	283	4.79	58	20.49	225	79.51		1.96	1.36	2.82	< 0.001
Radiotherapy + chemotherapy	1649	27.92	375	22.74	1274	77.26		0.93	0.72	1.20	0.552
Surgery + radiotherapy + chemotherapy	2661	45.06	735	27.62	1926	72.38		0.78	0.60	1.00	0.051
Service volume of physicians
Low (< 25%)	1492	25.26	284	19.03	1208	80.97		–	–	–	–
Middle (25–75%)	3109	52.64	807	25.96	2302	74.04		0.96	0.83	1.11	0.561
High (> 75%)	1305	22.10	431	33.03	874	66.97		0.81	0.67	0.97	0.023
Hospital level							< 0.001
Medical centers	3155	53.42	865	27.42	2290	72.58		–	–	–	–
Non-medical centers	2751	46.58	657	23.88	2094	76.12		0.74	0.31	1.77	0.501
Hospital ownership							< 0.001
Non-public	4092	69.29	1029	25.15	3063	74.85		–	–	–	–
Public	1814	30.71	493	27.18	1321	72.82		0.83	0.67	1.03	0.089

MDT multidisciplinary team, HR hazard ratio, NTD new Taiwan dollar.