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. 2021 Jun 25;6:240. doi: 10.1038/s41392-021-00562-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — AFAP1-AS1 promotes lung cancer metastasis. a Representative images of nude mouse lung tissues in three groups: A549 cells transfected with scrambled siRNAs and the empty vector (EV + NC, negative control), the pool of two siRNAs of AFAP1-AS1 (siAFAP1-AS1) or the AFAP1-AS1 overexpression plasmid (AFAP1-AS1) were injected into each nude mouse tail veins (n = 8 for each group), which were sacrificed 8 weeks later. b The metastatic nodules in the siAFAP1-AS1 group were much fewer than that in the EV + NC group, while that in the AFAP1-AS1 overexpression group was obviously more than that in the EV + NC group. c The lung metastatic nodules area on each mouse lung tissue surface. The metastatic area of the siAFAP1-AS1 group was smaller obviously and the AFAP1-AS1 overexpression group was much larger than that of the EV + NC group. Mean ± SD shows for data; n = 8 mice for each group. d Representative pictures of lung metastatic tumor foci after H&E staining (Scale bar: 20 μm and 50 μm). Data are presented as the means ± SD