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. 2021 Jun 25;6:240. doi: 10.1038/s41392-021-00562-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — AFAP1-AS1 promotes lung cancer cells migration and invasion through SNIP1. a Representative images from migration assays of A549 and PC9 cells transfected with scrambled siRNAs and the empty vector (EV + NC), AFAP1-AS1, or co-transfected with the AFAP1-AS1 overexpression plasmid and the two siRNAs pool targeting SNIP1. AFAP1-AS1 promoted cells migration, whereas knockdown of SNIP1 decreased the effect of AFAP1-AS1 (Scale bar: 200 μm). b Representative images of the invasion assays in A549 and PC9 cells transfected with scrambled siRNAs and the empty vector (EV + NC), the AFAP1-AS1 ovexpression plasmid or co-transfected with the AFAP1-AS1 overexpression vector and the pool of two siRNAs targeting SNIP1. AFAP1-AS1 promoted the invasion of the two cell lines, whereas knockdown of SNIP1 expression decreased the effect of AFAP1-AS1 (Scale bar: 200 μm). All experiments were repeated at least three times. Data are presented as the means ± SD