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. 2021 Jun 25;6:240. doi: 10.1038/s41392-021-00562-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — AFAP1-AS1 mediates the combination of SNIP1 and c-Myc proteins acting as a molecular guide. a Immunoprecipitation showed that the combination of SNIP1 and c-Myc was significantly weakened during overexpression of His-SNIP1 and Flag-c-Myc in A549 and PC9 cell lines knocked down for AFAP1-AS1. b Immunofluorescence of c-Myc and SNIP1 in A549 and PC9 cells after overexpression of His-SNIP1 and HA-c-Myc and knockdown of AFAP1-AS1. AFAP1-AS1 knockdown weakened the colocalization of SNIP1 and c-Myc proteins in A549 and PC9 cells. DAPI-stained nucleus: blue; anti-HA (c-Myc): red; anti-SNIP1: green; colocalization of c-Myc and SNIP1: yellow; the merged image represents the overlap of DAPI, c-Myc, and SNIP1 (Scale bar: 29 μm)