Table 1.
Clinical specimen, carbapenemase, PFGE-type and MLST results, for A. baumannii clinical isolates from Romania.
| Isolate | Source | Clinical Unit/Date | PFGE | MLST | Acquired carbapenemase | Antibiotic Resistance profile |
|---|---|---|---|---|---|---|
| A17 | Blood culture | A, January 2018 | III | ST2 | OXA-23*, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A15 | Pharyngeal exudate | A, January 2018 | II | ST2 | OXA-23*, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| 4542 | Pharyngeal exudate | A, December 2017 | I | ST2 | OXA-23*, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A9 | Stool culture | A, January 2018 | II | ST2 | OXA-23*, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A11 | Anal carriage | A, February 2018 | I | ST2 | OXA23*, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A07 | Blood culture | A, December 2017 | II | ST2 | OXA-23*, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A6 | Stool culture | A, November 2017 | II | ST2 | OXA-23*, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A12 | Anal carriage | A, February 2018 | I | ST2 | OXA-51, OXA-23 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A14 | Blood culture | A, February 2018 | I | ST2 | OXA-23*, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A10 | Stool culture | A, December 2017 | II | ST2 | OXA-23*, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A13 | Anal carriage | A, February 2018 | V | ST642 | OXA-24, OXA-51 | MEM, IMP, ETP, CEF, CXM, CTX, CAZ, CIP, FOX, FEP, ATM, AMC, PIP-TZP, SXT, AMK, GEN, NIT, LEV, TIG |
| A1 | Blood culture | A, October 2017 | IV | ST312 | OXA-24, OXA-51 | IPM, MEM, AMC, CTX, CAZ, PIP-TZP, CIP, LEV, GEN, AMK |
| A1prim | Blood culture | A, October 2017 | IV | ST312 | OXA-24, OXA-51 | IPM, MEM, AMC, CTX, CAZ, PIP-TZP, CIP, LEV, GEN, AMK |
| 8A | Urine | B, September 2017 | II | ST2 | OXA-23*, OXA-51 | IPM, MEM, PIP-TZP, CAZ, FEP, ATM, AMK, GEN, CIP |
| 7A | Urine | B, September 2017 | IX | ST2 | OXA-24, OXA-51 | IPM, CAZ, FEP, FOX, AMK, GEN, CIP, LEV, SXT, TET |
| 6A | bBood culture | B, September 2017 | VIII | ST636 | OXA-24, OXA-51 | IPM, MEM, CAZ, FEP, FOX, AMK, GEN, CIP, LEV, SXT, TET |
| 22s | Tracheal secretion | C, September 2017 | VI | ST636 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, PIP, IPM, MEM, SXT, FOX, LEV |
| 24s | Tracheal secretion | C, September 2017 | VI | ST636 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 21s | Catheter | C, September 2017 | VI | ST636 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, |
| 18s | Catheter | C, September 2017 | VI | ST1 | OXA-24*, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 19s | Urine | C, September 2017 | VII | ST492 | OXA-24, OXA-51* | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 29s | Tacheal secretion | C, September 2017 | VII | ST492 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 2s | Tracheal secretion | C, September 2017 | VI | ST636 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 33s | Tracheal secretion | C, September 2017 | VII | ST492 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 9s | Tracheal secretion | C, September 2017 | VII | ST492 | OXA-24, OXA-51* | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, TET |
| 14s | Catheter | C, September 2017 | VII | ST492 | OXA-24, OXA-51* | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 01s | Cerebrospinal fluid | C, September 2017 | VI | ST636 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 3s | Catheter | C, September 2017 | VI | ST636 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 4s | Tracheal secretion | C | negative | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, PIP, IPM, MEM, SXT, FOX, LEV, TET | |
| 10s | Tracheal secretion | C, September 2017 | negative | ST492 | OXA-24*, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, TET |
| 26s | Tracheal secretion | C, September 2017 | IV | ST312 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 24s prim | Tracheal secretion | C, September 2017 | VI | ST636 | OXA-24, OXA-51 | AMK, CAZ, FEP, CIP, GEN, PIP, IPM, MEM, SXT, FOX, LEV, TET |
| 4 new | Sputum | B, February 2018 | VI | ST636 | OXA-24, OXA-51 | MEM, FEP, GEN, SXT, LEV, TET |
1 Notes: A = ICU ; B- Ambulatory; C- Children Hospital. (*) indicates the ISAba1 insertion upstream of the gene encoding respective carbapenemase.
MEM = meropenem, IPM = imipenem, ETP = ertapenem, CEF = cephalotin, CTX = ceftriaxone, CXM = cefuroxime, FOX = cefoxitin, CAZ = ceftazidime, ATM = aztreonam, FEP = cefepime, AMC = amoxicillin-clavulanic acid, PIP-TZP = piperacillin-tazobactam, CIP = ciprofloxacin, LEV = levofloxacin, GEN = gentamicin, AMK = amikacin, NIT = nitrofurantoin, SXT = trimethoprim-sulfamethoxazole, TET = tetracycline, TIG = tigecycline.