Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 11;8:687783. doi: 10.3389/fcvm.2021.687783

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Raghavan, Kenchappa and Leo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

SARS-CoV-2 spike protein (Spike) increases endothelial permeability by downregulation of junctional proteins in diabetic endothelial cells. (A) Endothelial transwell permeability assay, mean data expressed as fold change. n = 6 for each, *P < 0.05 vs. untreated control, ^δP < 0.05 vs. untreated diabetic, ^#P < 0.05 vs. Spike-treated control. (B) Representative Western blot indicating expression of endothelial junctional proteins in endothelial cell culture with or without Spike treatment. (C) Mean data indicating fold change in protein expression. n = 6 for each, *P < 0.05 vs. untreated control, ^δP < 0.05 vs. untreated diabetic, ^#P < 0.05 vs. Spike-treated control.