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. 2021 Jun 25;36(2):109385. doi: 10.1016/j.celrep.2021.109385

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© 2021 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Neutralizing activity against SARS-CoV-2 variants

(A) Amino acid substitutions in the S protein of SARS-CoV-2 variants B.1.1.7, B.1.351, P.1, and mink cluster 5 are schematically shown.

(B) IC₅₀ values of mAbs (μg/mL) and plasma samples (dilution) against pseudoviruses with SARS-CoV-2 S variants are summarized with fold change (variant IC₅₀ value/614G IC₅₀ value).

(C) Neutralization of pseudoviruses with SARS-CoV-2 S variants (upper panels) and RBD mutants (lower panels) was examined by mAbs in 293FT/ACE2/TMPRSS2 cells. Data are represented as means ± SD (n = 3).

(D) IC₅₀ values of plasma samples from 14 patients with COVID-19 other than patients A and B were compared between the 614G pseudovirus and pseudoviruses carrying the variant S protein. Statistical analysis was performed using a Wilcoxon matched-pairs signed rank test, and p values are shown.