Figure 4.

Neutralization of authentic SARS-CoV-2

(A) A plaque assay was performed using the authentic SARS-CoV-2 Japan/NGS-IA-1/2020 strain and Vero cells. Representative result of plaque formation in the presence of mAb 9-105 is shown.

(B) Neutralization of authentic SARS-CoV-2 by mAbs and plasma samples are shown.

(C) IC₅₀ values of mAbs and plasma samples are summarized.

(D) Neutralization of authentic SARS-CoV-2 variants B.1.1.7, B.1.351, and P.1 by mAbs 10-121 and 9-105 are shown.

(E) IC₅₀ values of mAbs (μg/mL) against authentic SARS-CoV-2 variants are summarized with fold change (variant IC₅₀ value/prototype IC₅₀ value).

Data shown in (B) and (D) are represented as means ± SD (n = 3). See also Figure S2 for structure of 9-105 and S complex.