Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 11;8:693133. doi: 10.3389/fmolb.2021.693133

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Omran, Belcher, Mohile, Kesler, Janelsins, Hohmann and Kleckner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic of our hypothesis that CIPN symptoms are caused by (1) brain sensitization and compensation due to peripheral and spinal nerve damage and dysfunction, which is shown in the red box and is the focus of our novel review, plus two more well-studied phenomena: (2) spinal sensitization and compensation, and (3) peripheral nerve damage. Our hypothesis does not depend on whether chemotherapy enters the brain (green dashed arrows) for changes in the brain to contribute to CIPN symptoms. Image adapted from innerbody.com.