TABLE 1.

The effect of microRNAs (miRNAs) on blood–brain barrier (BBB) integrity.

Modulation of the BBB	miRNA	Target	Function	References
Tight junction	miR-15a/16-1	Claudin-5	BBB destructive	Ma et al., 2020
	miR-501-3p	ZO1	BBB destructive	Toyama et al., 2018
	miR-182	FoxO1	BBB destructive	Taddei et al., 2008
	miRNA-107	Endophilin-1	BBB destructive	Zhang et al., 2020
	miR-143	PUMA	BBB destructive	Bai et al., 2016
	miR-27a-3p	VE-cadherin	BBB destructive	Li et al., 2020
	miR-101	VE-cadherin	BBB destructive	Mishra and Singh, 2013
	miR-132	EEF2K	BBB protective	Xu et al., 2017
	miR-210	Occludin/β-catenin	BBB destructive	Ma et al., 2017
Inflammation	miR-125a-5p	N/A	BBB protective	Reijerkerk et al., 2013
	miR-155	N/A	BBB destructive	Lopez-Ramirez et al., 2014
	miR-21-5p	TNF-α/IL-6	BBB protective	Ge et al., 2016
	miR-126-3p	VCAM-1	BBB protective	Fu et al., 2019
	miR-98 and let-7g*	CCL2 and CCL5	BBB protective	Rom et al., 2015
	miR-1303	MMP9	BBB protective	Lampugnani et al., 2018
	miR-132	MMP9	BBB protective	Li et al., 2018
Supporting cells coverage	miR-27b	SEMA6A/D	BBB protective	Demolli et al., 2017
	miR-150	Tie-2	BBB destructive	Fang et al., 2016
Apoptosis/cell cycle	miR-182	mTOR	BBB protective	Zhang et al., 2020
	miR-285	Yki/Mask	BBB protective	Li et al., 2017
Actin cytoskeleton	miRNA-181c	PDPK1	BBB destructive	Tominaga et al., 2015
Channel and receptor	miR-30a	ZnT4	BBB destructive	Wang et al., 2021
	miR-27a-3p	AQP11	BBB protective	Xi et al., 2018