Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 11;12:701009. doi: 10.3389/fphar.2021.701009

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Zhang, Huang, Yao, Liu, Ruan, Nong, Chen, Fan, Wei, Wang, Sun, Li, Zhang, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of FA on cognitive- and emotional-related behaviors on postpartum female mice. (A) Schematic diagram of the experimental workflow on maternal and offspring. (B) Latency to reach the hidden platform in the training phase of the MWM. Two-way repeated measures ANOVA was used to analyze the latency during the navigation training: F (4, 36) = 31.08, p < 0.0001. *p < 0.05 Con + FA-H compared with Con. (C) FA administration increase the time spent exploring the target quadrant. One-way ANOVA: F (2, 27) = 20.45, p < 0.0001. (D) The spontaneous alteration rate and total number of entries were analyzed in the Y-maze task. One-way ANOVA: F (2, 27) = 24.46, p < 0.0001. One-way ANOVA: F (2, 27) = 0.2525, p = 0.7787. (E) Novel object discrimination were significantly improved after FA administration in postpartum female mice while had little effect on the preference for objects during familiarization. One-way ANOVA: F (2, 27) = 0.2078, p = 0.8137. One-way ANOVA: F (2, 27) = 11.84, p = 0.0002. (F) FA administration decreased the immobility time in the FST in postpartum female mice. One-way ANOVA: F (2, 27) = 8.665, p = 0.0012. The EPM results of time spent in open arms (G), the frequency of entries into open arms (H), and total arm entries (I) revealed treatment effects on anxiety. One-way ANOVA: F (2, 27) = 12.36, p = 0.0002. One-way ANOVA: F (2, 27) = 15.25, p < 0.0001. One-way ANOVA: F (2, 27) = 0.1126, p = 0.8939. (J) FA administration increased OFT center area exploring in postpartum female mice. One-way ANOVA: F (2, 27) = 6.74, p = 0.0042. Data were presented as scatter points plus mean ± SEM. n = 10 for each group. *p < 0.05; **p < 0.01; ***p < 0.001.