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. 2021 Jun 11;12:701009. doi: 10.3389/fphar.2021.701009

FIGURE 6.

FIGURE 6

Gestational FA administration promotes synaptic plasticity in postpartum female mice. (A) Representative immunoblots and quantifications showing Synaptophysin, Synapsin-1 and PSD95 expression in the hippocampus. Synaptophysin One-way ANOVA: F (2, 15) = 79.19, p < 0.0001. Synapsin-1 One-way ANOVA: F (2, 15) = 33.79, p < 0.0001. PSD95 One-way ANOVA: F (2, 15) = 11.23, p = 0.0010. Synaptophysin/PSD95 One-way ANOVA: F (2, 15) = 17.57, p = 0.0001. The Con group was normalized as a dotted line, and the statistical results were compared with the Con group. (B) Representative traces of fEPSP responses during LTP induction. Scale, 0.5 mV, 50 ms. (C) Time-course responses of the evoked LTP potentials following high frequency stimulation (HFS) at CA3-CA1 synapses. The points in the time scale axis were normalized to the average baseline response to show the fEPSP slope. (D) Area in the shadow showed the averaged %fEPSP slope during 46–50 min after stimulation in each group. One-way ANOVA was used to analyze the LTP during 46–50 min: F (2, 15) = 13.22, p = 0.0005. Data were presented as mean ± SEM. n = 6 for each group. *p < 0.05; **p < 0.01; ***p < 0.001.