Table 3.
Standard first-line chemotherapy regimens in HIV-associated lymphoproliferative diseases.
| - | Chemotherapy Regimen |
|---|---|
| Diffuse Large B cell Lymphoma (DLBCL) | R-CHOP or R EPOCH |
| Burkit Lymphomas (BL) | B-ALL protocols HyperCVAD / HD methotrexate |
| Hodgkins Lymphomas (HL) | Early Stage: ABVD 2 or 4 cycle in early favorable stage, eventually followed by 20-30 GY involved field radiotherapy according to number of cycles Advanced stage: 6-8 cycles of ABVD 5 cycles of BEACOPP |
| Primary Effusion Lymphoma (PEL) | CHOP or CHOP-like Bortezomib Lenalidomide |
| Primary Central nervous system Lymphomas (PCNSL) | High doses Metotrexate 1g /m2 and High doses cytarabime 3 g/m2 |
| Plasmablastic Lymphomas (PBL) | B cell Acute Lymphoblastic protocols |
Abbreviations: ABVD: Doxorubicin 25mg/m2 IV Bleomycin 10,000units/m2 IV Vinblastine 6mg/m2 IV Dacarbazine 375 mg/m2 R-CHOP CHOP: ciclofosfamide 750 mg/m2, doxorubicina 50 mg/m2, vincristina 2 mg, (rituximab 375 mg/m2 al giorno 1) e prednisolone orale 100 mg nei giorni 1–5) (R)EPOCH: (Rituximab) etoposide 50 mg/m2 prednisone 60 mg/m2, vincristine 0.4 mg/m2, cyclophosphamide 750 mg/m2, and doxorubicin 10 mg/m2 HyperCVAD: Cyclophosphamide 300 mg/m2, Vincristine 1,4 mg/m2, Doxorubicin 50 mg/m2 Dexametasone 40 mg orally BEACOPP: Bleomycin 10 mg/ m2, /Etoposide 100 mg/m2; doxorubicin 25 mg/m2, Vincristi14 mg/m2 (max 2 mg) 2, cyclophosphamide 650 mg/m2, Procarbazina 100 mg/m2, Prednisone 40 mg/m2.