Table 2.

Univariable and multivariable Cox regression analyses of characteristics with overall survival in TCGA cohort.

Variable	Univariate cox			Multivariate cox
	HR	CI95%	P Value	HR	CI95%	P Value
Age
≤65 or >65	1.161	0.832–1.619	0.38	1.23	0.867–1.744	0.246
Gender
Male or female	0.941	0.654–1.354	0.742	1.015	0.694–1.483	0.939
Current smoking
Yes or no	1.44	1.03–2.013	0.033	1.573	1.099–2.251	0.013
T stage
1, 2, or 3	1.25	0.941–1.66	0.124	1.293	0.905–1.849	0.159
N stage
0, 1, or 2	0.905	0.629–1.301	0.589	0.906	0.491–1.672	0.752
TNM stage
I or II	1.13	0.818–1.56	0.458	1.23	0.672–2.25	0.502
Mutation status
TTN MUT or WT	0.522	0.371–0.734	<0.001	0.643	0.428–0.966	0.034
TP53 MUT or WT	0.84	0.578–1.221	0.36	1.039	0.698–1.546	0.851
MUC16 MUT or WT	1.061	0.774–1.455	0.711	1.645	1.147–2.36	0.007
CSMD3 MUT or WT	0.763	0.554–1.051	0.097	0.942	0.661–1.343	0.743
RYR2 MUT or WT	0.741	0.531–1.035	0.079	0.635	0.44–0.915	0.015
LRP1B MUT or WT	0.95	0.679–1.329	0.765	1.044	0.715–1.523	0.824
USH2A MUT or WT	0.774	0.553–1.084	0.136	0.813	0.567–1.166	0.26
SYNE1 MUT or WT	0.719	0.51–1.015	0.061	0.874	0.606–1.26	0.47
ZFHX4 MUT or WT	0.845	0.597–1.195	0.341	1.008	0.682–1.491	0.966
FAM1358 MUT or WT	0.681	0.464–1.001	0.051	0.815	0.542–1.226	0.326
Risk score
Increasing	2.299	1.661–3.182	<0.001	2.396	1.679–3.419	<0.001