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. 2021 Jun 11;12:652136. doi: 10.3389/fphys.2021.652136

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Copyright © 2021 Coskun, Elbahi, Al-Karagholi, Ghanizada, Sheykhzade and Ashina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Changes in heart rate (bpm) were registered every 10 min. Heart rate did not differ between glibenclamide-CGRP and placebo-CGRP day. (B) Changes in mean arterial blood pressure (MAP) in mmHg. MAP did not differ between glibenclamide-CGRP and placebo-CGRP day. (C) Facial skin blood flow measured with Laser Speckle as changes in flux. No changes in AUC₀_–_{240 min} for facial skin blood flow were observed between glibenclamide-CGRP (157.5 ± 15.4) and placebo-CGRP day (160.8 ± 14.5; P = 0.3). (D) Blood glucose samples were drawn at 5 min intervals between 30 and 90 min, and at 10 min intervals hereafter. Blood glucose was clamped between 4 and 7 mmol/L.