TABLE 2.

Multiple growth factors play different roles in tendon repair (Molloy et al., 2003).

Growth factor	The phase in which the growth factor most active	Roles
IGF-1	Inflammation	Promotes the proliferation and migration of cells, stimulates matrix production
	Proliferation
TGF-β	Inflammation	Regulates cell migration, proteinase expression, fibronectin binding interactions, termination of cell proliferation, and stimulation of collagen production
VEGF	Proliferation	Promotes angiogenesis
	Remodeling
PDGF	Proliferation	Regulates protein and DNA synthesis at the injury site, regulates the expression of other growth factors
	Remodeling