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. 2021 Jun 11;12:695036. doi: 10.3389/fgene.2021.695036

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Copyright © 2021 Zhou, Shi, Cao, Yuan, Yu, Chen, Fang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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S100 calcium binding protein A10 (S100A10) is identified as a potential oncogene in hepatocellular carcinoma (HCC). (A) Volcano plot of the differentially expressed genes (DEGs). The red dots were increasing genes, and green dots were reducing genes in HCC tumor samples, respectively. (B) Identification of potential oncogene in HCC. Venn diagram of DEGs and differentially expressed proteins (DEPs) with miRNA-protein correlation > 0.45. Pie chart of 376 selected genes, including 167 (46 upregulated and 121 downregulated in HCC) survival-associated genes and 209 non-survival-associated genes. (C) Heat map of the 46 potential oncogenes.