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. 2021 Jun 11;8:663807. doi: 10.3389/fmed.2021.663807

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Copyright © 2021 Lindford, Juteau, Jaks, Klaas, Lagus, Vuola and Kankuri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Heatmap clustering of differentially expressed proteins in three consecutive tissue sections of 3 month follow-up control (c1-3) and injured (i1-3) biopsy samples. (B) Lactoferrin (LTF)-associated activated and inhibited pathways and identified differentially expressed proteins (DEPs) associated to each. (C) Top 3 predicted upregulated pathways and their associated DEPs. (D) Top 3 predicted inhibited pathways and their associated DEPs. Differentially expressed proteins and associated signalling pathways were analysed using Ingenuity Pathway Analysis (IPA).